Abstract
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB(2) affinity and CB(2) versus CB(1) selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
MeSH terms
-
Animals
-
Cell Line
-
Humans
-
Mice
-
Naphthyridines / chemistry*
-
Naphthyridines / pharmacology
-
Pain Measurement / drug effects
-
Pain Measurement / methods
-
Quinolines / chemistry*
-
Quinolines / pharmacology
-
Receptor, Cannabinoid, CB1 / agonists
-
Receptor, Cannabinoid, CB1 / biosynthesis
-
Receptor, Cannabinoid, CB1 / genetics
-
Receptor, Cannabinoid, CB1 / physiology
-
Receptor, Cannabinoid, CB2 / agonists*
-
Receptor, Cannabinoid, CB2 / biosynthesis
-
Receptor, Cannabinoid, CB2 / genetics
-
Receptor, Cannabinoid, CB2 / physiology
Substances
-
Naphthyridines
-
Quinolines
-
Receptor, Cannabinoid, CB1
-
Receptor, Cannabinoid, CB2